Thymoquinone Attenuates Diethylnitrosamine Induction of Hepatic Carcinogenesis Through Antioxidant Signaling
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چکیده
منابع مشابه
Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
Hepatocellular carcinoma accounts for about 80-90% of all liver cancer and is the fourth most common cause of cancer mortality. Although there are many strategies for the treatment of liver cancer, chemoprevention seems to be the best strategy for lowering the incidence of this disease. Therefore, this study has been initiated to investigate whether thymoquinone (TQ), Nigella sativa derived-com...
متن کاملin Liver Carcinogenesis by Diethylnitrosamine Role of Acute Hepatic Necrosis in the Induction of Early Steps
Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for y-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat. With the use of a necrogenic dose of diethylnitrosamine and an assay for the carcino...
متن کاملRole of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine.
Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat. With the use of a necrogenic dose of diethylnitrosamine and an assay for the car...
متن کاملThymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells.
Thymoquinone (TQ) is the major active compound derived from the medicinal Nigella sativa. In the present study, we investigated the anti-fibrotic mechanism of TQ in lipopolysaccharide (LPS)-activated rat hepatic stellate cells line, T-HSC/Cl-6. T-HSC/Cl-6 cells were treated with TQ (3.125, 6.25 and 12.5μM) prior to LPS (1μg/ml). Our data demonstrated that TQ effectively decreased activated T-HS...
متن کاملIs thymoquinone an antioxidant?
Background Thymoquinone is one of the active ingredients of black cumin (Nigella sativa L.) essential oil possessing antiinflammatory, antineoplastic, neuroand hepatoprotective properties. Some of these properties were attributed to an antioxidant activity of thymoquinone, which seems to be unlikely from its structure. Because the lipophilic thymoquinone exhibits a structural similarity with th...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2010
ISSN: 1942-0900,1942-0994
DOI: 10.4161/oxim.3.4.12714